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Smiles: O=C(NCCS(=O)(=O)C1=CC=C(C=N1)C(F)(F)F)C1C=CC(Cl)=CC=1
It can enhance survival of human embryonic stem cells (hESCs) or iPSCs after single cell dissociation by trypsin
Chemical Name: (S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2
Kiledjian M
EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 60100 Smiles: O=C(NCCS(=O)(=O)C1=CC=C(C=N1)C(F)(F)F)C1C=CC(Cl)=CC=1EPZ015666, also known as GSK3235025, CAS No. 1616391 65 1, is a potent and selective and orally active PRMT5 inhibitor with a half maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases. Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death, with IC50 values in the nanomolar range. Oral dosing with EPZ015666 demonstrated dose dependent