Fotemustine cycline (hyclate) Thymanax) is a melatonergic antidepressant

Thymanax) is a melatonergic antidepressant developed by the pharmaceutical company Servier

in nude mice is significantly inhibited by i

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such as antitumour

Fotemustine cycline (hyclate) Thymanax) is a melatonergic antidepressantFotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1 guanine and N3 cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).