TAS-103 dihydrochloride Size:Solid 2 mg Smiles: C[C@@H]1O[C@@H](C[C@H](NC(=O)C(F)(F)F)[C@@H]1O)O[C@H]1C[C@@](O)(CC2=C1C(O)=C1C(C(=O)C3=CC=CC(OC)=C3C1=O)=C2O)C(=O)COC(=O)CCCC

Smiles: C[C@@H]1O[C@@H](C[C@H](NC(=O)C(F)(F)F)[C@@H]1O)O[C@H]1C[C@@](O)(CC2=C1C(O)=C1C(C(=O)C3=CC=CC(OC)=C3C1=O)=C2O)C(=O)COC(=O)CCCC

InChiKey: QFSFPJHBIGWPMD-PBVGKYIBSA-N

3)4)52-37(55)23-58-17-18-59-32-13-9-28(10-14-32)34-20-36(49-24-48-34)51-30-11-15-33(16-12-30)60-43(44

Felodipine was approved by the FDA in 1991

TAS-103 dihydrochloride Size:Solid 2 mg Smiles: C[C@@H]1O[C@@H](C[C@H](NC(=O)C(F)(F)F)[C@@H]1O)O[C@H]1C[C@@](O)(CC2=C1C(O)=C1C(C(=O)C3=CC=CC(OC)=C3C1=O)=C2O)C(=O)COC(=O)CCCCTAS 103, also known as BMS 247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS 103 has been reported to be a potent topoisomerase II poison. TAS 103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0. 05). The combination with CDDP augmented the antitumor activity of TAS 103 (p<0. 05), indicating that CDDP is one of the most potent candidates