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Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase
HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases
Chemical Name: N-(4-(4-isopropoxybenzyl)phenyl)-4
PubMed PMID: 20919678
Vadimezan (DMXAA) Size:2mg solid Reduced SMAD7 leads to overactivationVadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti tumor activity of tumor associated macrophages. Product information CAS Number: 117570 53 3 Molecular Weight: 282. 29
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